Emirates Journal of Food and Agriculture 35(12): 1-8, doi: 10.9755/ejfa.2023.3188
Uric acid–reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia
expand article infoChih-Chiang Wang‡, Chun Chen§, Chih-Wei Chang|, Po-Yen Chiu|, Fu-An Chen|
‡ Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802 and School of Medicine, National Defense Medical Center, Taipei 114, Taiwan, Taiwan§ School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Taiwan| Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan, Taiwan
© Chih-Chiang Wang, Chun Chen, Chih-Wei Chang, Po-Yen Chiu, Fu-An Chen.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Wang C-C, Chen C, Chang C-W, Chiu P-Y, Chen F-A (2023) Uric acid–reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia. Emirates Journal of Food and Agriculture 35(12): 1-8. https://doi.org/10.9755/ejfa.2023.3188
Open Access
Abstract

Plectranthus amboinicus (Lour.) Spreng is a type of Lamiaceae perennial herb that is widely used in folk treatments for respiratory and skin diseases. Notably, research on the hypouricemic effect of P. amboinicus is limited. This study investigated the uric acid–reducing efficacy of P. amboinicus in mice with potassium oxonate-induced hyperuricemia by performing an in vitro xanthine-oxidase-inhibition-activity-guided test of P. amboinicus extract (PAE) and its fractions. The ethyl acetate fraction (EAF) of PAE exhibited optimal efficacy in terms of the phenolic content, DPPH scavenging activity, and xanthine oxidase inhibition. We further demonstrated the uric acid–reducing activity of EAF in a mouse model of potassium bromate–induced hyperuricemia. The results can serve as a useful preclinical reference for researching the gout prevention effects of functional foods.

Keywords: Plectranthus amboinicus (Lour.) Spreng, hyperuricemia, uric acid–reducing activity